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Folic acid when taken in a larger dose for a prolonged duration can impair the therapeutic response of Mecobalamin

Because of the possibility of bleeding, it is imperative that any modifiable risk factors are eliminated or reduced prior to initiation of warfarin therapy, appropriate monitoring of anticoagulation is performed, and the benefit of anticoagulation outweighs the risk for each patient

This is more frequently seen in infants but has happened in adults as well

The c-Abl inhibitor, nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinsons disease

mutations in SOD1 can induce oxidative damage in motor neuron mitochondria and trigger the clinical symptoms of ALS [116]