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Exploratory single-cell RNA sequencing (scRNA-seq) analyses of BM mononuclear cell subsets and gene expression at baseline and W52 (N=51,910 cells, Fig

KRAS is an oncogenic protein that is commonly activated in many tumors, including lung cancer and pancreatic cancer, and it has been considered an undruggable target because it lacks a classical drug binding site 143,144

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NNMTi was shown to have high permeability to the membrane in a bidirectional permeation assay in Caco-2 cells

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Ongoing support and regular follow-ups ensure continuous monitoring and adjustments to treatment plans as needed