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Moreover, PGE2 released by tumors upregulates CD73 expression in monocytic MDSCs, leading to increased suppression of T cell activity through elevated adenosine levels

For DKD, 590 individuals were included and divided into two groups: 413 patients with T2DM and severe DKD, and 177 participants with more than 10 years of T2DM and no history of DKD