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Symptoms of DPN vary according to the class of involved sensory fibers, presenting with pain and unpleasant sensations if small fibers are involved and with numbness and loss of protective sensation (LOPS) if large fibers are involved

Recently, eryptosis and the consequent accelerated clearance of circulating RBCs were mentioned as the mechanisms involved in the development of anemia in patients with hepatic disease

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4 Department of Endocrinology, Peoples Hospital of Kashgar, Kashgar, Peoples Republic of China Correspondence: Pan-Xia Wang, Department of Endocrinology, Peoples Hospital of Kashgar, Kashgar, Peoples Republic of China, Email [email protected] Sheng Jiang, Department of Endocrinology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Peoples Republic of China, Email [email protected] Abstract: Diabetic kidney disease (DKD), a major microvascular complication of diabetes, affects 30 40% of patients and is the leading cause of end-stage renal disease

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