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Although there is a relationship between low vitamin B12 levels and cognitive decline, clinical studiesincluding those involving people with Alzheimers diseasehave not shown improvement in cognitive function, even doses of the vitamin as high as 1000 micrograms, says Dr

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DIAGNOSTIC CRITERIA FOR VITAMIN B12 DEFICIENCY In situations where vitamin B12 levels are not markedly low, and there are no apparent symptoms, such as macrocytic anemia, it remains difficult to diagnose vitamin B12 deficiency based solely on the measurement of vitamin B12