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Open Access Review Role of oxidative stress and endoplasmic reticulum stress in drug-induced liver injury Affiliation: 1 Department of Immunology, Ophthalmology and ENT, Complutense University School of Medicine, 28040 Madrid, Spain These authors share the first authorship

4.1 Key molecular pathways ROS-induced in NSCs 4.1.1 NRF2 signalling Nuclear factor erythroid 2-related factor 2 (NRF2) has emerged as it represents the master regulator of the cellular defense against oxidative stress

282,283 Trimethylamine N-oxide, which is secreted by Clostridium species, can activate protein kinase RNA-like endoplasmic reticulum kinase-mediated endoplasmic reticulum stress, increasing antitumor immune responses and improving the efficacy of immunotherapy for triple-negative breast cancer

[3] [4] In human plasma, the level of GHK-Cu is about 200 ng/ml at age 20

Epidemiol 176, 573585 (2012)

Mitochondrial substrate-level phosphorylation as energy source for glioblastoma: review and hypothesis