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This effect of AMPK signaling is in agreement with our previous studies showing that, despite having 15% and 40% of WT total and mitochondrial GSH levels (respectively), livers from nave GCLM KO mice maintain structural and functional integrity of the mitochondria and show induction of ER stress-related genes 17,38

The upregulation of NRF2 and SOD1, along with the activation of ROS scavenging pathways, can lead to resistance to chemotherapy or targeted therapy in various tumors

Intravenous GSH has a short half-life but has shown to be effective in several diseases

Although we did not evaluate behavior in the current study, we demonstrated in a previous study on a hypoxia model (not NEC model), that NAC treatment significantly attenuated sensorimotor dysfunction in neonatal rats exposed to hypoxia 13