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Blocking FASN via orlistat or siRNA knockdown was found to inhibit transcription of HER2 by upregulating PEA3, a transcriptional repressor of HER2, although the molecular mechanism is not yet understood (Menendez et al., 2005a)

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Moreover, LC administrated for 2 weeks suppresses atrogin-1 messenger RNA (mRNA) level in suspended rats hindlimb [35], and only 7 days of LC administration downregulates MuRF-1 and atrogin-1 mRNAs reducing muscle wasting in a rat model of cancer cachexia [32]