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By stabilizing TDP-43 and facilitating its degradation, these chaperones attenuate its toxic gain-of-function effects

First, as mentioned above, many retrospective case-controlled studies show a clear-cut association between elevated plasma homocysteine and atherothrombotic disease

2024;18:1053-1081.[DOI] 23

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Keeping vitamin K 1 intake at a stable level can prevent these fluctuations

The strongest associations map to the human leukocyte antigen (HLA) region, particularly HLA class II (e.g., HLA-DRB1), with at least 16 HLA alleles linked to UC (Naito and Okada, 2022