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Neurosurg Focus (2006) 20(4):E7

[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Del Rio D., Zimetti F., Caffarra P., Tassotti M., Bernini F., Brighenti F., Zini A., Zanotti I

Efflux ABC transporters in drug disposition and their posttranscriptional gene regulation by microRNAs

At this point, we have previously shown that IGF-I is a main character in restoring mitochondrial dysfunction during aging by increasing mitochondrial membrane potential, reducing oxygen consumption, and increasing ATP synthesis what in turn minimize the c-cytochrome release to the cytoplasm and subsequently promote neural survival by decreasing caspase-induced apoptosis[55, 56], in agreement with in vitro reported works from others[242244]

10.1038/nature24297 64

Additional MPO-targeting drugs that are safe for clinical use must be developed