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Each sample was loaded onto individual Evotips for desalting and then washed with 200 L 0.1% FA followed by the addition of 100 L storage solvent (0.1% FA) to keep the Evotips wet until analysis

These antibodies bind to ECs and induce apoptosis, contributing to tissue damage (Fig

Figure 3 6.2 Energy substrates and metabolic characteristics of microglia Glucose is the primary energy source for microglial survival and function, with hypoxic glucose deprivation leading to microglial cell death (Kacimi et al., 2011

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10.1071/AN17269 130

In vivo biodistribution Nanoparticles ranging between 50 and 200 nm in size possess the ability to passively accumulate within tumor tissues through enhanced permeability and retention effect (EPR) effect, facilitated by damage vessel structure and lymphatic system [44]