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By ETC in chloroplast at PSI and PSII, ROS like 1 O 2 , O 2 , H 2 O 2 , and OH are produced through Chl* molecules

Hence, tier-2 targets follow a similar strategy to chemotherapeutics in cancer, which often impair regular cellular metabolic activity

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N Engl J Med 341 : 785792 Clemmons DR (1993) Use of growth hormone and insulin-like growth factor I in catabolism that is induced by negative energy balance

Some peptides act directly on endocrine glands

Apoptosis Pathway-Associated Proteins Are Frequently Expressed in Melanoma: A Study of 32 Cases With Focus on Acral Lentiginous Melanoma