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Aberrant activation of RIPK2 is closely associated with increased expression of signaling molecules in the colonic mucosa of IBD patients, and blocking RIPK2 activation effectively inhibits the development of experimental colitis in mice [463, 464]

Biochemical investigations showed a normal level of cysteinyl glycine in plasma, an abnormal urinary profile with increased excretion of cysteinyl glycine (4972 mmol/mol of creatinine) and leukotrienes with increased leukotriene D4 and complete absence of LTE4

NLRP3 plays a unique role within inflammasome-forming NLRs

The measurements were conducted twice, with a minimum interval of 2 min between each measurement

When conducting a tail suspension test, reduced immobility time is considered a success when considering antidepressive treatment whereas increased immobility is equated with depressive-like behavior

Hierbei muss beachtet werden, dass es fr die ersten drei dieser prinzipiellen Stufen keine studienbasierten Empfehlungen gibt, sondern es sich um klinische Konsenspunkte (KKP) handelt