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Oxidant formation can also arise via electron-leakage from mitochondria, from enzymes such as xanthine oxidase and lipoxygenases, and by uncoupling of enzymes such as endothelial and inducible nitric oxide synthases (NOS) (reviewed) 8

As a benchmark, Taxol, a well-established microtubule-stabilizing compound with known efficacy in SCI models, was included as a positive control 21

2,3 More These statements have not been evaluated by the Food and Drug Administration

However, these signals can travel with the circulatory system and reach different tissues, not only confined to the lungs

doi: 10.1007/s12035-022-03148-z 48

Liu L, Yang X, Zhao F, Gao C, Zhang N, Bao J