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Ly C, Zhang W, Yu G, Mu H, Zhang H, Rice WG, and Andreeff M

Without enough glutathione to conjugate and clear the histamine, these inflammatory chemicals recirculate through the body, causing systemic MCAS symptoms like severe brain fog, hives, rapid heart rate (tachycardia), and profound digestive distress

These moderated t-tests in DESeq2 are shrinkage-based two-sided Wald tests (H 0 : log 2 FC = 0), which incorporate empirical Bayes moderation to improve dispersion estimation across genes, allowing for more reliable inferences 85

doi: 10.1016/S0140-6736(13)62227-8 180 ClinicalTrials.gov

7 Therapeutic strategies and clinical translation With the deepening understanding of ferroptosis mechanisms, an increasing number of molecular targets have been identified as closely associated with the pathological progression of AD