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Wang L, Ahn YJ, Asmis R

152 Experimental findings have suggested that the oxidation of Met residues by cigarette smoke or free radicals released from inflammatory cells not only reduces the anti-elastase activity of AAT but also converts AAT into a proinflammatory molecule

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However, there are several avenues of research that may help mitigate these side effects while successfully downregulating immunosuppressive pathways

10.1038/s41418-018-0225-1 Cell Death Differ

The vascular phenotype of the conditional deletion was milder than that of the germ line deletion (Fig 2A and B), likely due to delayed onset of the loss of Gpr124 function after tamoxifen injection