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42 The incorporation of RGD has been demonstrated to significantly enhance chondrogenesis, as evidenced by the increased mRNA expressions of Sox9, collagen II, and aggrecan as well as elevated levels of aggrecan and collagen II expression

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For example, in their 1967 study describing purification and properties of an acidic protein from chromaffin granules of bovine adrenal medulla (chromogranin A), Albert David Smith and Hans Winkler reported that although this protein was shown to have a molecular weight of 77 kDa based on the sedimentation, diffusion, and approach-to-equilibrium measurements, results of chromatography on a Sephadex G-200 column calibrated with globular proteins gave a molecular weight 7 times that given above

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