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Disclosures: David Martinus: Nothing to Disclose, David Fuentes: Nothing to Disclose, Michelle Luster: Nothing to Disclose, Uma Ramamurthy: Nothing to Disclose, Fasiha Kanwal: Nothing to Disclose, Saira Khaderi: AstraZeneca: Advisor, Hashem El-Serag: Nothing to Disclose, Eugene Koay: Nothing to Disclose 1908 MULTISTEP ACCUMULATION OF MISMATCH REPAIR DEFICIENCY-ASSOCIATED MUTATIONAL SIGNATURE DURING THE HEPATOCARCINOGENESIS REVEALED BY WHOLE-GENOME SEQUENCING ANALYSIS Haruhiko Takeda 1 Atsushi Takai 1 Masayuki Ueno 1 Yosuke Fujii 1 Masako Mishima 1 Tadashi Inuzuka 1 Hiroshi Seno 1 , 1 Kyoto University Graduate School of Medicine Background: Mismatch repair deficiency (dMMR) is one of the established biomarkers predicting the efficacy of immune checkpoint inhibitors

Patients with recent injection drug use (within 6 mo) were assigned to the PWID arm, and those who hadnt injected within 6 months but agreed to be in the study and signed consents, were assigned to the non-PWID arm

EMT is an important mode for cancer cells to spread

Alfadda AA, Sallam RM

Limit your sugar intake Speaking of your diet, giving up sugar is another crucial step in overcoming mold toxicity since sugar is the preferred fuel source of fungi, including mold and yeasts like candida

SD, standard deviation