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They are not regulated under FDA drug manufacturing standards

Experimental models have demonstrated that AKI can lead to chronic damage of renal parenchyma, resulting in CKD, indicating that early intervention may impact long-term outcomes (151)

Furthermore, TNF- promotes the production of other pro-inflammatory cytokines, such as IL-1 and IL-6, further exacerbating the inflammatory response

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They are a natural byproduct of metabolism or caused by exposure to toxins in the environment such as tobacco smoke, UV light, and alcohol