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Novel Insights Into Ferroptosis

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded in the mitochondrial genome, first identified in research published in Cell Metabolism in 2015

However, the present study did not test equivalence for the hierarchical model

This effect is likely to be mediated through several pathways: a) Upregulation of antioxidant enzymes: The significant increase in catalase levels observed in the IF group suggests that IF enhances endogenous antioxidant defenses, as catalase is a key enzyme in detoxifying hydrogen peroxide and mitigating oxidative stress

Besides, the multi-target property and favorable biocompatibility makes TCM a viable option for combining with chemotherapy to enhance treatment outcomes while reducing side effects [27,28,29]

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