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May 2014;234(1):85-92

According to a 2017 review published in American Family Physician (AAFP), the prevalence of vitamin B12 deficiency in the United States and the United Kingdom is approximately 6% in persons younger than 60 years, and nearly 20% in those older than 60 years

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If the immunocompromised recipient is age 5 years or older, once the initial series is complete, any appropriate brand may be used for all subsequent doses

Their use should involve appropriate professional guidance, even though some products containing these peptides are available over the counter