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Distinguished features of SOD3 include: Contains copper and zinc as cofactors, similar to SOD1 Forms a homotetramer with a high affinity for heparin and other glycosaminoglycans Particularly abundant in blood vessels, lungs, and kidneys Plays a crucial role in protecting the extracellular matrix and cell surfaces Important for vascular health and blood pressure regulation SOD3's extracellular location makes it especially relevant for protecting against oxidative stress in the vascular system, where it helps maintain endothelial function and vascular tone

Finally, we would like to acknowledge Silvan Urfer, Anthony Grillo, and Shauna Hill for their assistance with necropsies and sample collection

CrossRef Effect of dapagliflozin on liver and pancreatic fat in patients with type 2 diabetes and non-alcoholic fatty liver disease Mengran Shi, Hao Zhang, Wei Wang, Xiao Zhang, Jiawei Liu, Qixian Wang, Yuan Wang, Chunlin Zhang, Xiaoqin Guo, Qiao Qiao, Chun Cui, Jing Xu, Jian Wang Journal of Diabetes and its Complications .2023

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