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It was found that H 2 S significantly inhibited hypoxia-induced pulmonary VSMCs and reversed chronic hypoxia-induced PH by suppressing endoplasmic reticulum (ER) stress markers in both in vivo and in vitro models (Wu et al., 2019)

Li et al (38) reported that treatment of HepG2 cells with copper sulfate resulted in prominent ER swelling under a microscope

doi: 10.1164/rccm.201309-1575OC 108 LeeSYLeeJSLeeSWOhY-M

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

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Zn is necessary for the activation of antioxidant enzymes that scavenge reactive oxygen species (ROS), thereby reducing oxidative stress (67)