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Tastuzawa Y, Sekinaka K, Suda T, Matsumoto H, Otabe H, Nonoyama S, et al

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The PBT-CBT-gradient provides a reliable measure for inner heat conductance and predicts the increase in N3

Without robust blood flow, the disc's ability to repair itself is profoundly limited

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The base mechanism is identical, so if the modified versions really do achieve substantially higher effective tissue concentrations per administered milligram, then a lower administered dose makes sense