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The gut microbial metabolites 5-(3,4-dihydroxyphenyl)--valerolactone and 5-(3-methoxy-4-hydroxyphenyl)--valerolactone revealed with approximately 30% a rather low binding to albumin

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Compared with the intramuscular route, intranasal administration of a recombinant adeno-associated virus vaccine encoding SARS-CoV RBD induced significantly higher titres of mucosal IgA in the lung and reduced lung pathology upon challenge with SARS-CoV 3