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As we continue to learn more about the health ravages of using combustible tobacco, as rates of smoking decline, and as smoking becomes more and more a marginalized behavior, it will become increasingly difficult for those who purport to be in the health business to simultaneously sell one of the most deadly products

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It is also worth noting that DNA methylation is only one type of epigenetic modification, hence efforts should be made to investigate further epigenetic mechanisms, including histone modifications and non-coding RNA

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