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doi:10.3389/fendo.2018.0024 71

doi: 10.1210/clinem/dgz252 117 ZouRNieCPanSWangBHongXXiSet al

Activated NLRP3 inflammasomes can also activate caspase-8, which in turn activates downstream caspase-3 to initiate apoptosis [256]

Bilirubin, which exerts as an direct activator for TRPM2, was most recently found to be released in the brain subjected to oxygen-glucose deprivation (OGD), and to aggravate brain damage in the stroke in a manner strongly sensitive to molecular perturbation of the bilirubin-binding site on TRPM2 (Liu et al., 2023)