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doi: 10.1126/sciadv.1500472

Mild issues like water retention or joint discomfort can also occur

By proposing mitochondria as a potential player, this review provides a fresh framework for investigating hEDS, shifting the focus from solely ECM abnormalities to include cellular energetics and mitochondrial dynamics

Personality traits: Individuals with low self-esteem, a pessimistic outlook, or who are highly self-critical may be more prone to developing depression

It is associated with microbial translocation from the gut into the interstitium and perivascular tissues resulting in systemic inflammation, abnormalities of lipid and glucose metabolism, atherosclerosis, and hypertension