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This increases the risk of drug accumulation, renal toxicity, and drug-drug interactions

Antioxidants 13(2):182 Mishima E et al (2020) Drugs repurposed as antiferroptosis agents suppress organ damage, including AKI, by functioning as lipid peroxyl radical scavengers

PXR, Pregnane X receptor

It increased the relative abundance of Bacteroides while reducing Escherichia and Shigella spp., alongside upregulating occludin and downregulating claudin-2