cagrisema semaglutide cagrilintide phase 3 results 2024 2025 obesity Presenters to provide first look at data from REIMAGINE trials of cagrilintide/semaglutide for type 2 diabetes management Novo Nordisk's next-gen obesity drug

Jan 3, 2026 Dark circles under eyes create persistent cosmetic concern affecting appearance across all ages and skin types, with multiple underlying causes including thin periorbital skin revealing underlying vasculature, hyperpigmentation from melanin accumulation, shadows from volume loss and fat pad descent, and fluid retention creating puffiness accentuating darkness

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Laboratory investigations continue to examine its potential interactions with skin elasticity, dermal architecture, pigmentation and age-related structural changes

doi: 10.1111/j.1753-4887.2010.00352.x

While IGF-I remains the biomarker that best reflects endogenous GH secretion, when there is a discordancy with GH and IGF-I levels, it is important for the clinician to be mindful of the associated changes in intra-portal insulin delivery to the liver when interpreting these results in the context of health and when deciding treatment regimens in disease states

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