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Caspase 8 polymorphisms contribute to the prognosis of advanced lung adenocarcinoma patients after platinum-based chemotherapy

In normal conditions, extracellular superoxide dismutase (SOD3) is expressed in high concentrations in the lungs and is responsible for removing extracellular superoxide anions, a type of free radical contributing to oxidative stress

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Artesunate and dihydroartemisinin may ameliorate lung tissue inflammation through the HMGB1/TLR4/NF-B pathway and alleviate lung injury induced by various factors, these compounds decrease inflammatory cell infiltration, immune cell (macrophages, neutrophils, eosinophils, and lymphocytes) counts, and inflammatory mediator (TNF-, IL-1, IL-6, IL-10, IL-12, and TGF-) levels (Li et al., 2023