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RECOMMENDATION: Use small needle by deep intramuscular injection

Contribution statement All the persons listed as authors fulfil all three criteria for authorship as per the ICMJE uniform requirements

Despite this, cyanocobalamin has been increasingly criticised in recent years, due to the following reasons: Toxicity: cyanocobalamin is often claimed to be toxic, as the cyano group form the poison cyanide

Although we did not detect changes in Setd2 expression in the colon and stomach with reprogramming (Extended Data Fig

All studies have been conducted using 80 g4 mg/kg/day and ranging in a wide spectrum of lengths (weeks to months) and routes of administration