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This same study found that DSIP may be useful ir patients with a physiologic dependence on other pain medications as it helps to reduce withdrawal svmptoms and the pain rebound that often occurs following cessation of long- term analgesic therapy

Sareen-Khanna, K., Papillon, J., Wing, S

5-Rs isoforms (types 1, 2 and 3) are widely distributed in many tissues including the central nervous system, and inhibition of these enzymes results in blockade of synthesis of several key hormones and neuro-active steroids ( Figure ) leading to a host of adverse effects, including loss of or reduced libido, erectile dysfunction, orgasmic dysfunction, increased high Gleason grade prostate cancer (PCa), observed heart failure and cardiovascular events in clinical trials, and depression

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3,4 Further cytokine production can occur as the LL37/DNA complex can act as an auto-antigen by fitting into the groove of human leukocyte antigen-Cw6 that is then presented to the T-lymphocyte

Diarrhoea, nausea or vomiting