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Sample size in the hundreds, follow-up of several months, prespecified primary endpoint, independent funding or at least transparent funding disclosure, replication of key findings

NLRP3 knock-out reduced these effects, suggesting that an IL-1-dependent NLRP3/caspase-1 neuroimmune pathway is a key driver of fatigue and providing a rationale for targeting this axis therapeutically [77]

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Expression of type 2 iodothyronine deiodinase in hypothyroid rat brain indicates an important role of thyroid hormone in the development of specific primary sensory systems

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By modulating specific cortical areas involved in mood regulation, executive function, pain perception, and autonomic balance, we can support patients experiencing brain fog, chronic pain, anxiety, depression, burnout, and post-stress nervous system dysregulation