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The cells were incubated for another 6 h, and cell viability was measured as previously described

Topical application of a glutathione amino acid precursor formulation to ex vivo skin samples prior to UVB irradiation led to a significant suppression of cyclobutene pyrimidine dimers (CPD), markers of DNA damage

The increase in proline levels can be understood as a primary stress response

All animals were housed at Animal Experiment Center of Wenzhou Medical University under the following conditions: 3 mice/ cage (30 20 15 cm, length width height), 12 h dark/light cycle, room temperature (24 1) C, ambient humidity (50 10) %, with free access to food and water

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This study offers an additional explanation of the various detrimental routes through which DOX causes acute nephrotoxicity in experimental animals, specifically rats