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Solid lipid nanoparticles: a review of their biomedical applications and preparation

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During the development of osteoarthritis, the synovium undergoes interstitial vascularization, fibrosis and hyperplasia (167), and macrophages and fibroblasts in the synovium can release proinflammatory cytokines, etc., which cause synovitis and cartilage degeneration

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Additionally, cirrhosis and viral hepatitis patients show a higher incidence of OSA compared to control groups and patients with severe symptomatic ascites develop sleep disturbances due to secondary OSA (35)

This cytosolic pseudo-starvation signal, caused by the sequestration of iron within the mitochondrial matrix and the concomitant failure of ISC biogenesis, triggers a compensatory but ultimately maladaptive response [2,99,100]