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and a family history of Lynch-associated malignant disorders, including endometrial, colorectal, ovarian, gastric, pancreatic, small bowel, urothelial and/or biliary tract cancers, in 2 or more first- or second-degree relatives

10.1016/j.jep.2023.116268 88 LaPlacaM

Loncar, G., Omersa, D., Cvetinovic, N., Arandjelovic, A

Some irAEs, such as thyroid disease, are treatable and the damage reversible

Pro-inflammatory cytokines induce mitophagy as a protective response, and mitophagy-deficient -cells accumulated dysfunctional mitochondria and had increased cell death, whereas overexpression of Clec16 rescued viability and mitophagy in human -cells (Sidarala et al., 2020)

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