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Oxidative stress is a result of an imbalance between ROS levels and antioxidative defense systems [121]

The accumulation of -amyloid increases oxidative stress and intracellular Ca 2+ influx, promoting neuronal toxicity in cases of Alzheimers disease ( in vitro studies on other natural compounds and computational or theoretical approaches, and should therefore be considered hypothetical, as direct in vitro or in vivo experimental data specific to bromelain are lacking

participation in the maturation of iron-sulfur clusters in proteins Build heart & brain tissue, improve immune response

Front Plant Sci 12:663750

Consequently, the results indicated that SMR may inhibit the TNF signaling pathway by modulating the expression of COX-2, IL-6, and TNF- (143)

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