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RSL3 is known to interact with thioredoxin reductase 1 (Txnrd1) which also plays a role in DNA damage and oxidative stress 31

The importance of considering circadian rhythm and metabolic regulation in drug design is emphasized

Therefore, further elucidating the pathogenesis of RA and identifying new therapeutic targets will help develop more personalized, effective, and safe treatment approaches, thereby improving the quality of life of RA patients and reducing the socioeconomic burden of the disease

doi: 10.1038/s41598-017-10734-y 147 WanetA.ArnouldT.NajimiM.RenardP

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The reactive SH group of glutathione can form a thioether by reacting with C=C double bonds, carbonyl groups or other reactive groups forming a glutathione conjugate