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The top dose produced 20.9% average weight loss over 72 weeks and 20.2% in a direct comparison with semaglutides 13.7%. Its second receptor, GIP, separates tirzepatide from approved single-receptor GLP-1 drugs and helps explain the larger population-level weight loss. That 20.9% came from participants averaging about 105 kg at a BMI of 38, most of whom were sedentary

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In addition to their insulinotropic effects, they have a number of roles in tissues that express GLP-1 and/or GIP receptors, including the pancreas, brain and adipose tissue (Table S1, Supplementary Appendix) [6]

Mol Med 4(6):376383 Khafif A et al (2005) Curcumin: a new radio-sensitizer of squamous cell carcinoma cells

Metabolic studies with acetylcysteine