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The most widely accepted pathway, proposed by Challenger et al

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International J Mol Sci 24(4):3899

One of the most clinically advanced NRF2 activators is dimethyl fumarate, marketed as Tecfidera by Biogen Idec

Fogarasi M, Socaci S, Dulf F, Diaconeasa Z, Farcas A, Tofana M, Semeniuc C (2018) Bioactive compounds and volatile profiles of five transylvanian wild edible mushrooms