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However, many patients require extended treatment, and risks and benefits should be discussed with a doctor

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Similarly, -lipoic acid, through its disulfide/dithiol redox pair, not only neutralizes SOD, OH, and ROO radicals but also regenerates other antioxidants like GSH and vitamin C, making it a valuable addition in managing diabetic neuropathy and metabolic syndrome [43]

The study design is illustrated in Figure 1

Other commenters recommended CMS consider WAC and AWP based payment methodologies

It functions as a cofactor for lysyl oxidase (the enzyme responsible for collagen cross-linking and stabilization), ceruloplasmin (a copper transport protein with antioxidant activity), and superoxide dismutase (SOD, a primary antioxidant defense enzyme)