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In 2016 Biovista, a drug repurposing company engaged to find a drug combination that might work for ME/CFS, proposed that trazodone plus low-dose naltrexone should get tested in ME/CFS

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In one study, a combination of L-theanine, vitamins B6, B9, B12 and rhodiola, was beneficial for treating chronic stress in otherwise healthy subjects (19)

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If the presence of an initial stressor is prolonged, the HPA axis will become chronically activated and trigger the overproduction of cortisol which, over time, will result in a reduction in cortisol levels (427)