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607 In functional studies, astrocytes differentiated from stem cells obtained from familial AD showed aberrant Ca 2+ signalling, 608,609 increased production of reactive oxygen species, reduced lactate supply, compromised neuroprotection, and inability to support neurones in co-cultures

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One mechanism that contributes to cytochrome c detachment from IMM involves cardiolipin oxidation because oxidized cardiolipin has a much lower affinity for cytochrome c than the reduced form

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