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These collective findings demonstrate that VPA exposure induces systemic oxidative stress, characterized by concurrent antioxidant depletion (CAT, GSH-Px, GSH, SOD) and elevation of oxidative damage markers (MDA, T-NOS, NO)

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In this sense, while high doses of NR did not lead to improvements in insulin sensitivity in pre-diabetic patients [16,54], low doses of NMN improved insulin sensitivity in pre-diabetic women [99]

Proteostatic pathways are deregulated in middle-aged and aged Mda5 -/- HSCs To investigate the molecular mechanism underlying the youthful phenotype of Mda5 -/- HSCs, we performed bulk RNA-sequencing (RNA-seq) to compare young, middle-aged, and aged WT and Mda5 -/- HSC transcriptomes

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