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Furthermore, transplantation of the KD gut microbiota and suppletion of Akkermansia muciniphila and Parabacteroides decreased seizure frequencies even in mice on a normal diet ( Clinical data also show that the KD influences gut microbiota composition in children with DRE, resulting in increased levels of Bacteroidetes ( To unravel the correlation between the human gut microbiome and neurological diseases including epilepsy, metagenomics holds great potential ( Phosphoglycerate Dehydrogenase and the Serine Synthesis The KD has recently been shown to induce the expression of genes involved in the serine synthesis, such as PHGDH, in the liver and cerebral cortex of mice (Supplementary Figure 1)

10.1016/j.phymed.2012.12.005 102 HarmanD

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Parasitol Res 102:981988 Kim JK, Choi MS, Jeong JJ, Lim SM, Kim IS et al (2018) Effect of Probiotics on Pharmacokinetics of Orally Administered Acetaminophen in Mice

Autophagy-related genes (Atg) play a role in this process, among which Atg5 and Atg7 are crucial for the formation of autophagosomes [68]

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