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Roles of host mitochondria in the development of COVID-19 pathology: could mitochondria be a potential therapeutic target

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GSH is used by glutathione peroxidases, and can exchange with mixed disulfides to yield GSSG

Since GSH is not carried inside the cell, exogenously administered GSH is most likely to act by increasing plasma GSH levels reducing luminal oxidative stress and increasing NO bioavailability in patients with endothelial dysfunction (220)

10.1016/j.cell.2025.03.005 258 LeeH.-J.LeeK.-E.KimJ.-K.KimD.-H

Severe neonatal jaundice from acute hemolysis can also arise from a G6PD-deficient infants exposure to environmental oxidative compounds