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Together, these forces erode mitochondrial function, damage DNA, and slowly push cells toward dysfunction and death [38, 39]

It might be argued that for the long time scale of PD progression, apoptosis is an acute cellular event that on the surface does not perfectly explain the development of PD, but when patients start to have detectable parkinsonism symptoms, there is usually at least 4060% dopaminergic neuronal loss in the substantia nigra ( c do not mean that it releases cyt c and activate caspases immediately

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