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Abbreviations AA: Arachidonic acid BAP: Bioartificial islet transplantation BP: Black phosphorus bHb: Bovine hemoglobin DHCNPNPs: Camouflaged biomimetic nanocomposites CAT: Catalase Ec: Cell-free hemoglobin DAC: Decitabine DHL: DOX-Hb-lipo DM: Diabetes mellitus EBFC: Enzyme biofuel cells EM: Erythromer FDA: Food and drug administration G-HbOD: Gelatin hemoglobin depot GelMa: Gelatin methacryloyl GM: Gelatin microspheres GLUT1: Glucose transporter isoform 1 HCM: Hb-conjugated micelles Hb: Hemoglobin HbV: Hemoglobin vesicles HBOCs: Hemoglobin-based oxygen carriers HbPs: Hemoglobin-loaded nanoparticles HbTcMs: Hemoglobin-polymer conjugate HS: Hemorrhagic shock HDAS: Hexadecyl carbamoyl methyl hexadecanoate V(Hb): Hollow nanovesicles HeLa: Human cervical cancer cells hHb: Human hemoglobin HSA: Human serum albumin HIF-1: Hypoxia inducible factor-1 HRP: Horseradish peroxidase ICG: Indocyanine green LEH: Liposome-encapsulated human hemoglobin h-LEH: Liposomes encapsulating hemoglobin RCC: Renal cell carcinoma Lt: Lumbricus terrestris MMP-9: Matrix metalloproteinase-9 MPA: Mean arterial pressure MOFs: Metalorganic frameworks MNs: Microneedles MCAO: Middle cerebral artery occlusion MnPcs: Mn-phthalocyanine CT-26: Mouse colon cancer models MDR1: Multidrug resistance gene 1 NERBCS: Nanoengineered red blood cells NEMR: Nanoerythrocytes Nano-HBOCs: Nanomaterial-related HBOCs I-ARCs: Nanoscale artificial blood cells NIR: Near-infrared OHZ: O 2 @Hb@ZIF-8 OXA: Oxaliplatin oxyHb: Oxyhemoglobin PFCs: Perfluorocarbons P-gp: P-glycoprotein PDT: Photodynamic therapy PDT: Photodynamic therapy PS: Photosensitizer PLT: Platelets PDA: Polydopamine PWS: Port-wine staining PE: Pre-eclampsia RT: Radiation therapy ROS: Reactive oxygen species RBCs: Red blood cells FRET: Resonance energy transfer effect SDT: Sonodynamic therapy SOD: Superoxide dismutase tMCAO: Transient MCAO TME: Tumor microenvironment TAM: Tumor-associated macrophage ZnPc: Zinc phthalocyanine References Motealleh A, Kehr NS

Genes Dev 26(4):325337 Chen X, Qi J, Wu Q et al (2020) High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression

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