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Lidamycin, an antitumor antibiotic, has also been reported to induce mitophagy in PDAC cells by regulating the expression of MFN2 [93]

The preferred sequence of each feature of the fusion protein construct, from the 5 to 3 direction with each feature being operably linked to the other, would be a promoter, signal sequence, X number of (CAD)x domains, the furin sequence (or other proteolytic sequence), and the coding sequence of the polypeptide of the present invention